Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lhx2  LIM homeobox protein 2   (Synonyms: ap, apterous, Lh-2, LH2A)
Results	Reference
1*	J:207154 Balasubramanian R, Bui A, Ding Q, Gan L, Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Gene Expr Patterns. 2014 Jan;14(1):1-8
1	J:226335 Bhattacharya S, Wheeler H, Leid M, Ganguli-Indra G, Indra AK, Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1. J Invest Dermatol. 2015 Nov;135(11):2593-602
1	J:196674 Cederquist GY, Azim E, Shnider SJ, Padmanabhan H, Macklis JD, Lmo4 establishes rostral motor cortex projection neuron subtype diversity. J Neurosci. 2013 Apr 10;33(15):6321-32
1	J:332685 Chen GD, Fatima I, Xu Q, Rozhkova E, Fessing MY, Mardaryev AN, Sharov AA, Xu GL, Botchkarev VA, DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation. Sci Adv. 2023 Jan 13;9(2):eabo7605
1	J:235552 Chinn GA, Hirokawa KE, Chuang TM, Urbina C, Patel F, Fong J, Funatsu N, Monuki ES, Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice. Cereb Cortex. 2015 Sep;25(9):2707-18
1	J:173617 de Melo J, Peng GH, Chen S, Blackshaw S, The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons. Development. 2011 Jun;138(11):2325-36
1	J:231601 de Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S, Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405
1	J:271140 Diacou R, Zhao Y, Zheng D, Cvekl A, Liu W, Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation. Cell Rep. 2018 Nov 27;25(9):2510-2523.e4
1	J:306056 Doyle DZ, Lam MM, Qalieh A, Qalieh Y, Sorel A, Funk OH, Kwan KY, Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2100686118
1	J:65763 Eggenschwiler JT, Anderson KV, Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev Biol. 2000 Nov 15;227(2):648-60
1*	J:257927 Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simo S, RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
1	J:178994 Fantauzzo KA, Christiano AM, Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012 Jan;139(1):203-14
1	J:202029 Folgueras AR, Guo X, Pasolli HA, Stokes N, Polak L, Zheng D, Fuchs E, Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell. 2013 Sep 5;13(3):314-27
1	J:253958 Fujimura N, Kuzelova A, Ebert A, Strnad H, Lachova J, Machon O, Busslinger M, Kozmik Z, Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation. Dev Biol. 2018 Jan 1;433(1):47-60
1	J:199799 Gordon PJ, Yun S, Clark AM, Monuki ES, Murtaugh LC, Levine EM, Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. J Neurosci. 2013 Jul 24;33(30):12197-207
1	J:237540 Gueta K, David A, Cohen T, Menuchin-Lasowski Y, Nobel H, Narkis G, Li L, Love P, de Melo J, Blackshaw S, Westphal H, Ashery-Padan R, The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis. Development. 2016 Nov 15;143(22):4182-4192
1	J:212598 Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E, NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 2008 Jan 25;132(2):299-310
1	J:326220 Hoye ML, Calviello L, Poff AJ, Ejimogu NE, Newman CR, Montgomery MD, Ou J, Floor SN, Silver DL, Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. Elife. 2022 Jun 28;11:e78203
1	J:333564 Javed A, Santos-Franca PL, Mattar P, Cui A, Kassem F, Cayouette M, Ikaros family proteins redundantly regulate temporal patterning in the developing mouse retina. Development. 2023 Jan 15;150(2):dev200436
1	J:193195 Katoh K, Yamazaki R, Onishi A, Sanuki R, Furukawa T, G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70
1	J:331939 Keil JM, Doyle DZ, Qalieh A, Lam MM, Funk OH, Qalieh Y, Shi L, Mohan N, Sorel A, Kwan KY, Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nat Commun. 2020 Jul 31;11(1):3839
1	J:222438 Klimova L, Antosova B, Kuzelova A, Strnad H, Kozmik Z, Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development. Dev Biol. 2015 Jun 1;402(1):48-60
1	J:335074 Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J, Skoultchi AI, Stopka T, Kozmik Z, Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Cells. 2023 Mar 28;12(7)
1	J:329268 Langouet M, Jolicoeur C, Javed A, Mattar P, Gearhart MD, Daiger SP, Bertelsen M, Tranebjaerg L, Rendtorff ND, Gronskov K, Jespersgaard C, Chen R, Sun Z, Li H, Alirezaie N, Majewski J, Bardwell VJ, Sui R, Koenekoop RK, Cayouette M, Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration. Sci Adv. 2022 Sep 9;8(36):eabh2868
1	J:241102 Leone DP, Panagiotakos G, Heavner WE, Joshi P, Zhao Y, Westphal H, McConnell SK, Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation. Cereb Cortex. 2017 Feb 01;27(2):1686-1699
1	J:207483 Li Y, Hao H, Tzatzalos E, Lin RK, Doh S, Liu LF, Lyu YL, Cai L, Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3(2):172-84
1	J:336095 Lupan BM, Solecki RA, Musso CM, Alsina FC, Silver DL, The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis. Development. 2023 May 15;150(10)
1	J:297667 Menuchin-Lasowski Y, Dagan B, Conidi A, Cohen-Gulkar M, David A, Ehrlich M, Giladi PO, Clark BS, Blackshaw S, Shapira K, Huylebroeck D, Henis YI, Ashery-Padan R, Zeb2 regulates the balance between retinal interneurons and Muller glia by inhibition of BMP-Smad signaling. Dev Biol. 2020 Dec 1;468(1-2):80-92
1	J:324116 Morita R, Sanzen N, Sasaki H, Hayashi T, Umeda M, Yoshimura M, Yamamoto T, Shibata T, Abe T, Kiyonari H, Furuta Y, Nikaido I, Fujiwara H, Tracing the origin of hair follicle stem cells. Nature. 2021 Jun;594(7864):547-552
1	J:133475 Nakamura M, Ishikawa O, The localization of label-retaining cells in mouse nails. J Invest Dermatol. 2008 Mar;128(3):728-30
1	J:155012 Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E, Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet. 2009 Oct;41(10):1068-75
1	J:321803 Niu F, Han P, Zhang J, She Y, Yang L, Yu J, Zhuang M, Tang K, Shi Y, Yang B, Liu C, Peng B, Ji SJ, The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. Elife. 2022 Feb 18;11:e75827
1*	J:290212 Noto M, Noguchi N, Ishimura A, Kiyonari H, Abe T, Suzuki T, Hasunuma N, Taira M, Manabe M, Osada SI, Sox13 is a novel early marker for hair follicle development. Biochem Biophys Res Commun. 2019 Feb 19;509(4):862-868
1	J:207286 Nowak JA, Polak L, Pasolli HA, Fuchs E, Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell. 2008 Jul 3;3(1):33-43
1	J:313370 Pena-Jimenez D, Fontenete S, Megias D, Fustero-Torre C, Grana-Castro O, Castellana D, Loewe R, Perez-Moreno M, Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo. EMBO J. 2019 Oct 1;38(19):e101688
1	J:142349 Prasad T, Wang X, Gray PA, Weiner JA, A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster. Development. 2008 Dec;135(24):4153-64
1	J:110119 Rhee H, Polak L, Fuchs E, Lhx2 maintains stem cell character in hair follicles. Science. 2006 Jun 30;312(5782):1946-9
1	J:179784 Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T, miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci. 2011 Sep;14(9):1125-34
1	J:238111 Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML, Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation. Stem Cells. 2016 Jul;34(7):1896-908
1	J:270947 Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE, Regional Control of Hairless versus Hair-Bearing Skin by Dkk2. Cell Rep. 2018 Dec 11;25(11):2981-2991.e3
1	J:212275 Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X, Pygo2 regulates beta-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10215-20
1	J:159209 Tornqvist G, Sandberg A, Hagglund AC, Carlsson L, Cyclic expression of lhx2 regulates hair formation. PLoS Genet. 2010;6(4):e1000904
1	J:171421 Vandunk C, Hunter LA, Gray PA, Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011 Apr 27;31(17):6457-67
1	J:306055 Weir K, Kim DW, Blackshaw S, A potential role for somatostatin signaling in regulating retinal neurogenesis. Sci Rep. 2021 May 26;11(1):10962
1	J:235394 Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD, Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep. 2016 May 3;15(5):999-1012
1	J:280461 Xiao D, Jin K, Xiang M, Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development. Front Mol Neurosci. 2018;11:271
1	J:195242 Youssef KK, Lapouge G, Bouvree K, Rorive S, Brohee S, Appelstein O, Larsimont JC, Sukumaran V, Van de Sande B, Pucci D, Dekoninck S, Berthe JV, Aerts S, Salmon I, del Marmol V, Blanpain C, Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol. 2012 Dec;14(12):1282-94
1	J:223313 Zembrzycki A, Perez-Garcia CG, Wang CF, Chou SJ, O'Leary DD, Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6736-41
1	J:334713 Zhang J, Roberts JM, Chang F, Schwakopf J, Vetter ML, Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1. Cell Rep. 2023 Mar 28;42(3):112237
1	J:225537 Zhang J, Taylor RJ, La Torre A, Wilken MS, Cox KE, Reh TA, Vetter ML, Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation. Dev Biol. 2015 Jul 15;403(2):128-38